Rubik's Puzzle Galaxy: RUSH is a puzzle game where the flow of rolling cubes needs to be managed to bring them to their destination. Each of the puzzles is set on a floating platform of blocks, with elevated elements. There are squares of different colours that show in which direction the cubes will roll. The player's goal is to introduce signs to the playfield to influence the movement of the cubes, making sure they do not collide or disappear off the playfield. The cubes flow autonomously and the player cannot influence them once the sequence has been started. To make a cube disappear, it needs to rolls into a square of the same colour.
For each of the 70 levels players have a limited number of signs at their disposal. Directional signs (arrows) move the cube's direction when they roll over them, split signs send them left and right, alternatively, and warp points move a cube to a new location. The last type is the conveyor sign. It is similar to the directional sign, but it does not change the orientation of the cube, it just transports it. Next to that, cubes will automatically turn right and continue rolling when they bump into a wall. Once all signs have been placed (with no time limit) the player starts the sequence to test it. There is an unlimited number of retries for each level.
The 70 puzzles are divided over three difficulty levels (the harder are initially locked), along with a bonus world. For each level players can choose from a number of puzzles, skipping hard ones for instance, and completing one unlocks more environments on the main map. While placing the signs, the camera can be rotated freely in any direction. There is a limited amount of hints. After placing the signs the hint button can be activated and a green or red overlay shows whether they are correct. Squares that require a sign but do not have one are marked with white lines. Placing the signs is done through a drag-and-drop mechanic.
The Wii version references the famous Hungarian Rubik's Cube puzzle and contains an additional mode. Players can attempt to solve one of the four available cubes, each with a different size, or learn how to solve a classic Rubik's Cube.